An efficient synthetic method for the preparation of 2-phenylethanamine thiazoline using Pd(PPh3)4 as an effective catalyst under mild conditions

Ilyas Mellah

Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 2

An efficient synthetic method for the preparation of 2-phenylethanamine thiazoline using Pd(PPh3)4 as an effective catalyst under mild conditions

Abstract

An efficient synthetic method for the preparation of 2-phenylethanamine thiazoline with good yield is described by using Pd(PPh3)4 as an effective catalyst under mild conditions for deprotection of Allyloxy carbonyl (Alloc) group. The use of (CH3CO2)2Pd2+ ,(C17H14O)2Pd, C16H24Cl2Ir2, (COD)2Ni, AuCl3 was unsuccessful whereas the use of iodine I2 in presence of DMSO led to thiazole.