Numbers of thiazoles, thiazolodinones, thiazinanones and imidazolones have been synthesized in a quantitatively yield in an accessible method via one pot reaction technique using the precursor amino alcohols. In vitro antimicrobial properties of the newly synthesized compounds have been scanned and discussed. It showed the thiazole 6e possessed the highest inhibitory effect against Micrococcus luteus, model Gram-negative bacteria. Thiazolidinone 4a and thiazole 6a showed the highest activity against E. coli, model Gram-positive bacteria compared with Ampicillin. All compounds have been characterized by FT-IR, NMR and X-ray.