Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 4

An efficient One pot Synthesis of 1, 4-Dihydropyridine Derivatives under Solvent free Condition


Synthesis of 1, 4 – Dihydropyridines were accomplished by the condensation of Acetoacetnilide, Aromatic aldehydes and Ammonium acetate in the presence of Bismuth trichloride as catalyst under solvent free condition. Excellent yields (83% to 96%) with less reaction time (15 to 20 min.) and easy workup are the novelty of this reaction. These compounds were colourless, pale yellow and reddish brown crystalline solids. These compounds structures were elucidated with the help of spectral studies -- IR, 1H NMR, 13 C NMR, Mass and Elemental analysis.