Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 8

An easy route to synthesis of thiophene tagged pyrimidin-2-thiones as antibacterial agents

Abstract

A series of substituted pyrimidin-2-thiones tagged with thiophene moiety was synthesized by an easy procedure. The reaction of chalcones 1-5 and thiourea 6 in the presence potassium hydroxide in ethanol yielded 6-aryl-4-(thiophen- 2-yl) -5,6-dihydropyrimidin-2(1H) -ones, 7-11 in good yields. The synthesized new compounds were characterized by 1H NMR, 13C NMR, Mass spectral studies and elemental analysis and were screened for their antifungal susceptibility against different bacteria species.

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