Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 2

Ameliorative effects of Zingiber officinale extracts against experimentally-induced hepatotoxicity in rats

Abstract

The ameliorative effects of Zingiber officinale extracts against paracetamol induced hepatotoxicity in rats was experimentally investigated. Fifty- four (54) adult male albino rats comprising of nine normal and forty-five paracetamol hepatotoxic rats were used. Paracetamol hepatotoxicity was induced by single administration of paracetamol at 750mg/kg ip on the first day of the experiment. The biochemical parameters assessed were determined before the start of the study and subsequently monthly for the duration of the study. Blood samples were collected from the rat through the retro orbital plexus for analysis and serum was obtained by centrifugation (5000rpm for 10mins) and stored at -20oC prior to analysis. The ameliorative effects of duration and increasing dosages (200, 300 and 450mg/kg) of Z. officinale extracts produced a duration dependent significant (p < 0.05) reductions in the alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and total serum bilirubin (TSB) of paracetamol hepatotoxic rats after the duration of study when compared with those of the paracetamol, normal and silymarin control rats. Z. officinale reduced alanine aminotransferase, total serum bilirubin and lactate dehydrogenase levels in a dose dependent fashion whereas it reduced aspartate aminotransferase and alkaline phosphatase levels in a dose independent manner. It was evident that Z. officinale showed potent hepatoprotective properties as it ameliorated significantly all the elevated biochemical parameters due to paracetamol hepatotoxicity. Given the findings of this study, the clinical relevance of Z. officinale in hepatoprotection and its nutraceutical role in human nutrition could be pursued in future studies.