Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2018 Vol: 10 Issue: 6

Alteration in Serum Sex Hormonal Level after Long-Term Administration of Lagenaria siceraria Fruit Powder in Female Rats


Background. This research work was to emphasis the consequence of Lagenaria siceraria fruit powder (LSFP) on serum estrogen, FSH, LH and progesterone hormonal level in Wistar rats. Method. In present research female rats received 300, 500 and 1000 mgkg-1 body weight of the LSFP. Female rats were separated into four groups; control group (vehicle only), low dose group (300 mgkg-1), medium dose group (500 mgkg-1) higher dose group (1000 mgkg1). Suspension of LSFP in 2% gum acacia was administered orally for ten weeks. 24 h. from the last doses of LSFP, blood samples were withdrawn by puncturing retro-orbital plexus and serum estrogen, FSH, LH and progesterone hormonal levels were assessed by using ELISA immunoassay technique. Results. A significant rise in serum estrogen level at the doses 1000 mgkg-1, while reduction in serum FSH and LH levels at 500 mgkg-1 and 1000 mgkg-1, furthermore, fall in serum progesterone levels at a dose of 1000 mgkg-1 of LSFP treated rats were observed. Organ morphology depicted rise in ovarian uterine weights at the doses 500 mgkg-1 and 1000 mgkg-1. Histological observation not revealed any changes in architect of ovary. All results from treatment group were compared with that of control group rats. Conclusion. An effect of LSFP on serum sex hormonal profile in female Wistar rats might be due to the phytosterols or 5-alpha-reductase enzyme inhibition.