Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

Acute Myocardial Infarct????±on Ischemia of The Erythtrocyte Oxidative Stress In The Role Of Nitric Oxide


Acute myocardial infarction (AMI) patients' that ischemia / reperfusion injury to, the information is controversial anti-oxidant enzymes. Thrombolytic therapy in studies that compared the values before and after treatment, erythrocyte antioxidant activity has been reported that an increaseddecreased or remained unchanged. Acute inflammatory events, nitric oxide (NO) as a paradox of both protective and damaging effect is remarkable. In our study, ischemia during AMI because of the variable state parameters of oxidative stress malondialdehyde (MDA) and superoxide dismutase (SOD) and NO in plasma and red blood cell measurements, and the latter with the evaluation was to determine erythrocyte has acted as an antioxidant. This study in 50 patients with a diagnosis of AMI and 30 healthy adult human, a total of 80 persons were taken into consideration. After obtaining blood samples, plasma and red blood cell pellet samples stored at -80 until analysis. Thiobarbituric acid method of MDA, SOD activity and NO levels of nitroblue tetrazolium method, the modified cadmium reduction method, were measured spectrophotometrically. Acute MI group than the control group, plasma MDA and NO values were significantly higher (p <0.005), whereas erythrocyte MDA levels were similar in the control group. On the other hand, erythrocyte SOD activity and NO levels in the AMI group, low in the control group (p <0.005) were found to be. NO levels of patients diagnosed with AMI and the significant decrease in erythrocyte SOD, erythrocyte SOD, catalase (CAT) and glutathione peroxidase (GPx), which consists of the first cellular line of defense may play a role also suggests that NO. AMI showed a significant increase in plasma MDA levels, erythrocyte MDA levels, while not exhibiting, supports this opinion.