Acoustical and volumetric properties have been measured for substituted heterocyclic compounds drugs and compounds in dioxane-water mixture at 303K. The measurement have been perform to evaluate acoustical parameter such as adiabatic compressibility (bs), Partial molal volume (fv), intermolecular free length (Lf), apparent molal compressibility (fk), specific acoustic impedance (Z), relative association (RA), salvation number (Sn).