Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2011 Vol: 3 Issue: 3

A validated non-aqueous potentiometric titration method for the quantitative determination of Azelnidipine from pharmaceutical preparation


A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of azelnidipine from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.99 ) between 20 % to 100 % of 100 mg of drug substance weight. The percentage recovery of azelnidipine in the optimized method was between 100.03 % to 101.85 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

rtp slot demo