The title compounds have been prepared by incorporating the anthranilic acid with substituted benzoylchloride which lead to the formation of oxazin-4-ones followed by subjecting it in the presence of pyridine, hydrazine hydrochloride, sodium cyano oxide lead to the formation of 1-(4-oxo-2-arylquinazolin-3(4H)-yl) semicarbazide. Various aromatic carbonyl compound with 1-(4-oxo-2-arylquinazolin-3(4H)-yl) semicarbazide in the presence of glacial acetic acid and ethanol gives (S1-S10) quinazoline derivatives. Structures of newly synthesized compound have been established on the basis of their IR and NMR spectral data. All the synthesized compounds have been screened for their antimicrobial activity.