1,4 Dichlorobenzene (1,4 DCB) has been used as a space deodorant and moth repellant as well as an intermediate in the chemical industry. Given its broad applications and high volatility, considerable concern exists regarding the adverse health effects of 1,4 Dichlorobenzene in the home and the workplace. In this study changes in lipid peroxidation, antioxidants and liver marker enzyme in the serum of 1,4 DCB treated rats were investigated to determine their roles in toxicity. The rats were given 300mg/kg of DCB then treated with Glycyrrhiza glabra Linn., leaf extract. The level of malindealdehyde (MDA), an end product of lipid peroxidation, markedly increased in the 1,4 DCB treated rats, after treating with Glycyrrhiza glabra Linn., extract its level returned to its original level. Thus G.glabra exhibits its best antioxidant potential and liver protective effects like strand drug – silymarin.