The antioxidative effect of ( 5x10-6 – 1x10-3 ) mol.L-1 of some additives on adrenaline (AD) oxidation in a weak acid media (pH =5.7), in the presence of ethylene diamine tetraacetic acid EDTA has been investigated by spectrophotometric method , based on the formation of the colour oxidation product (adrenochrome) in the light of the knowledge of accelerated AD oxidation reaction kinetics with K2Cr2O7 using as oxidant. At a very low additives concentration of about (5x10-6) mol.L-1 there is almost no inhibitory effect has been observed. However, in the same concentration, EDTA increases the inhibitory effect of additives , the increasing are probably due to change in the mechanism of antioxidant oxidation.