Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2017 Vol: 9 Issue: 4

A Simple and One Step Commercially Cost Effective Process for Eluxadoline Intermediates


Methyl-5-formyl-2-methoxybenzoate (1) and (S)-alpha-Methyl-4-phenyl-1H-imidazole-2-methanamine (2) are key intermediates in the synthesis of Eluxadoline drug. We described a new cost effective process for synthesis of Methyl-5-formyl-2-methoxybenzoate (1) with salicylic acid, Methanesulfonic acid, Hexamethylenetetramine and (S)-alpha-Methyl-4-phenyl-1H-imidazole-2-methanamine (2), with boc-L-Alanine and 2-chloroacetophenone. All the synthetic results were confirmed by ESI-MS and NMR analysis.

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