Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2011 Vol: 3 Issue: 6

A Simple and Efficient Synthesis of New Substituted Benzothienopyridazine Spiro- Derivatives of Pyrazolone, Pyrimidinone and Diazepinone


Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1 was used as a starting material to synthesize 2a-c via coupling with acetyl acetone, ethylcyanoacetate or malononitrile, respectively. Heating under reflux in sodium ethoxide solution 2a-c gave 3a-c. When compounds 3a-c were heated under reflux in ethanol with hydrazine hydrate, thiourea or 1,2-diaminoethane and a catalytic amount of piperidine to produce the spiro compounds 4a-c, 5a-c and 6, respectively.