Diabetes mellitus is a metabolic disorder of the endocrine system. The disease occurs worldwide and its incidence is increasing rapidly in most parts of the world. Moreover, continuous use of the synthetic anti-diabetic drugs causes side effects and toxicity. Therefore, seeking natural and non-toxic anti-diabetic drugs is necessary for diabetic therapy. Medicinal fruits play an important role in the development of potent therapeutic agents. The present paper reviews the data reported on pharmacologically active phytoconstituents obtained from fruits involved in anti-diabetic activity along with pharmacological status which have been experimentally studied for hypoglycaemic activity. This work stimulates the researchers for further research on the potential use of medicinal fruits having anti-diabetic potential