Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Short commentary: 2025 Vol: 17 Issue: 1

A Rare Case of Sister Joseph Nodule in Carcinoma of Colon Diagnosed by Fine Needle Aspiration Cytology

Abstract

Umbilical skin metastasis, also known as Sister Mary Joseph nodule, is a rare manifestation of advanced malignancies, most commonly associated with gastrointestinal and gynecological cancers. Its occurrence in colon carcinoma is particularly uncommon, with limited documented cases. This report discusses a 61-year-old male with a history of mucinous carcinoma of the colon treated with hemicolectomy and chemotherapy. The patient presented two years later with a swelling on the anterior abdominal wall, later identified as a metastatic deposit near the umbilicus. Clinical examination, imaging studies and Fine-Needle Aspiration Cytology (FNAC) confirmed the malignant nature of the lesion, consistent with metastasis from colon carcinoma. Umbilical metastasis indicates advanced disease and poor prognosis, underscoring the need for comprehensive diagnostic evaluation. This case highlights the importance of recognizing such atypical presentations and their diagnostic challenges in metastatic disease.

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