Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 4

A one-pot microwave irradiation synthesis of 1,2,4-triazolo[1,5-a]pyrimidines


Synthesis of a series of triazolopyrimidines (4a-j) was achieved from different acetoacetamides, thiophene-2- carbaldehyde and 5-amino-1,2,4-triazole using microwave irradiation within 20-30 minutes with high yield. The structures of the products were supported by FTIR, PMR and mass spectral data.