Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 1

A Novel Catalyst for One-pot Synthesis of Tetrahydrobenzo[b]pyran derivatives

Abstract

We report herein the use of Nickel nitrate hexahydrate (Ni(NO3)2.6H2O) as a new catalyst for the one-pot Biginellilike reaction coupling of dimedone, malononitrile and aromatic aldehydes to afford the corresponding Benzo-[b]- pyran derivatives in aqueous media to avoid the usage of hazardous organic solvents. The experimental conditions have been thoroughly optimized and established, allowing significant rate enhancements and excellent yields.