Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 1

A New Approach for the Synthesis of Some Novel Sulphur Bridged Pyrazoles and their Characterization


Reaction of derivatives of ethyl vinyl ether or ketene dithioacetal substituted with alkyl and aryl groups with hydrazine hydrate afforded respective pyrazole derivatives. This on subsequent treatment with α-halosubstituted acyl halide resulted in the respective N-acylated derivative. Reaction of N-acylated derivative with mercaptoheterocyclic compounds in the presence of base resulted in the formation of Sulphur bridged pyrazole derivatives.

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