The main objective is to prepare a drug from natural herbs and to optimize the component molecules in the drug using computational algorithms. Natural way of medication is advisable to avoid side effects. A natural drug has been proposed, out of herbs available in hilly regions of Tamilnadu. And Genetic Algorithmic (GA) approach is introduced for optimizing the natural drug prepared from various herbs. A variety of clinical tests like SDAI, CDAI is discussed. These tests are conducted clinically for finding out the activity of the disease. Simulated tests for optimizing the various 10 different combinations based on random weights of the natural drug is conducted. Selecting the best combination based on ACPA is done. This Siddha or Ayurvedic approach will be very useful for RA affected patients, when it is optimized using computer algorithms like GA. Also the various clinical tests for finding the activity of RA disease are studied.