Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

A Facile Microwave Assisted Synthesis and Antimicrobial Activity of Some Active Intermediates


The concept of green chemistry is now widely adopted to meet the scientific challenges of protecting the human health and environment. Microwave heating is very attractive for chemical applications and has become a widely accepted non-conventional energy source for performing organic synthesis. We schematized here a microwave assisted synthesis of some active intermediates such as substituted chromones (3a-b), substituted acrylophenones (4a-l) of biological importance by using substituted 1,3– propanediones(2a-c) in presence of catalysts PPA and TEBA. Claisen condensation of (1a-c) with ethyl acetate under powerful basic medium afforded corresponding diketones (2a-c). Cyclization of (2a-c) in presence of inorganic polymer (PPA) afforded corresponding chromones (3a-b). Condensation of (2a-c) with substituted aldehydes in presence of phase transfer catalyst (TEBA) afforded the corresponding acrylophenones (4a-l). The structures of the synthesized compounds have been confirmed on the basis of chemical analysis , spectral analysis ( IR, 1H-NMR) and elemental analysis. The purity of compounds has been checked by HPLC technique. Some of synthesized compounds have been screened for their antimicrobial activities.