A series of novel derivatives of triazolopyrimidine s were synthesized by a one-pot reaction of 3-amin o-1,2,4- triazole, different acetoacetamides and aryl aldehy des in using heating within 30 min. The structures of the target compounds were confirmed by inspection of their 1H- NMR, IR and MS spectra. The advantages of this met hod are short reaction times, good yields, high selectivity and operational simplicity.