Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 7

4-Hydroxy-3-[(3-hydroxy-2-oxo-1H-indol-3-yl)acetyl)-1-methyl-3,4- dihydroquinoline-2-ones as anti-inflammatory and antioxidant agents


4-Hydroxy- 1-methyl-3-[(2-oxo-1,2-dihydro- 3H-indol-3-ylidine) acetyl-3,4-dihydroquinolin-2(1H)-ones were characterized by means of Chromatographic and IR, 1H NMR and Mass spectral analysis. These compounds were evaluated for anti-inflammatory activity. Compounds IVC (R=5-Br), IVD (R=5-Cl), IVE (R=7-Br) and IVG (R1=7-Cl) were found to be the more active compounds towards carrageen induced rat paw edema model, and antioxidant activity by DPPH method. Compounds IVA (5-H), IVB (5-CH3), IVC (5-Br) and IVD (5-Cl) were found to be the less potent antioxidant compounds when compared to the standard drug ascorbic acid.