Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Synthesis of New Series of Bis-Benzothiazole Derivatives as DNA Minor Groove Binding Agents

Author(s): Ming-Li Yang and Xiu-Jun Wang

A series of novel bis-benzothiazole derivaties with head-to head orientation were synthesised, and their anti-proliferative activities on U937, HL60 and HeLa cells were investigated. Most of these new compounds showed significant in vitro anticancer activity when compared to 5-FU. Molecular modeling, fluorescence and viscosimetry study showed that these compounds could bind into the minor groove of DNA.

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