Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Synthesis of Ketoconazole Impurity by novel method

Author(s): Swapnali Patil

The aim of the work was to synthesize 1-[4-[[(2RS, 4SR)-2-(2, 4-dichlorophenyl)-2-(1H- imidazol-1-ylmethyl) -1, 3-dioxolan-4-yl] methoxy] phenyl] piperazine, i.e. impurity D of Ketoconazole which is an antifungal drug. Impurity was synthesized in a very conventional method and Elemental analysis was done by Mass spec troscopy and Proton NMR.

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