Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Synthesis, Characterisation and Biological Evaluation of Pyridazine Derivatives

Author(s): Rudresh HM*, Monica Arora, Slevakumar Balaraman, Datendranath Tripathi

A series of 5-substituted(2,3-d)pyridazin-8(7H)-one derivative was synthesized from pyridine dicarboxylic acid, Characterized and evaluated for anticonvulsant activity by Maximal Electroshock (MES) and the subcutaneous-PTZ method using 25 mg/kg of each compound against standard drugs Phenytoin 25 mg/kg and diazepam 4 mg/kg respectively. Among the synthesized derivatives, compounds 5a (100%), and 5b (100%) showed potential activity by the complete abolition of the hindlimb extensor in the MES method, and compounds 5g (72.2%) and 5a (57.4%) showed significant protection against the subcutaneous-PTZ method. Synthesized compounds 5b, 5c, and 5e also exhibited good anti-inflammatory activity against Indomethacin.

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