Synthesis, antimicrobial and antitubercular screening of new azetidinone
derivatives

Adesh Dubey; Anjali Tiwari; Santosh Kumar Srivastava

Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Synthesis, antimicrobial and antitubercular screening of new azetidinone derivatives

Author(s): Adesh Dubey*, Anjali Tiwari, and Santosh Kumar Srivastava

Some N-[(2-oxo-3-chloro-4-substituted phenyl-azetidineimino)-propyl] derivatives bearing indole moieties have been synthesized and evaluated in vitro for their antitubercular activity against Mycobacterium tuberculosis H37Rv and antimicrobial activity against a panel of bacteria and fungi. All these compounds were fully characterized by spectroscopic methods and elemental analysis. Some of the tested compounds showed moderate to excellent antitubercular and antimicrobial activities.

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