Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Synthesis and Antimycobacterial Properties of Fluorinated Benzaldoximes [Article Retracted]

Author(s): MM Kauhanka, IM Slabko and UM Kauhanka

Full range of fluorsubstituted benzaldoximes were synthesized by reaction of the fluorine-substituted benzaldehydes with hydroxylamine sulphate in the presence of sodium acetate in methanol. Trifluoromethyl- and 4-methoxy-fluorosubstituted benzaldoximes were synthesized also. Antimycobacterial properties of the synthesized compound were studied with the non- pathogenic strain Mycobacterium terrae 15755. The antimycobacterial activity of these substances is comparable to currently used anti-TB agents (pyrazinamide and isoniazide) with MIC ≥200 μg/mL.

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