Novel synthesis of ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H -imidazole-5-carboxylate: A key intermediate of olmesartan

Junrong Jiang; Weiqiang Yang

Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Novel synthesis of ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H -imidazole-5-carboxylate: A key intermediate of olmesartan

Author(s): Junrong Jiang and Weiqiang Yang

A novel method for synthesis of ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5 -carboxylate(2), a key intermediate of Olmesartan was reported. The compound 2 was synthesized from starting material ethyl oxalate (4) and ethyl chloroacetate (5) by three steps. The final compound was purified by simple acid-base treatment to get a product with 99.5% HPLC purity.

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