Microwave-assisted, solvent-free, acidic Al2O3-ZnCl2 catalyzed synthesis of aromatic hydroxyketones via Fries rearrangement of aromatic esters

Fozia Ashraf; Rajni Khajuria; Khaliquz Zaman Khan

Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Microwave-assisted, solvent-free, acidic Al2O3-ZnCl2 catalyzed synthesis of aromatic hydroxyketones via Fries rearrangement of aromatic esters

Author(s): Fozia Ashraf, Rajni Khajuria and Khaliquz Zaman Khan

A convenient synthesis of various aromatic hydroxyketones via Fries rearrangement is described by condensing a series of aromatic esters with acidic Al2O3-ZnCl2 mixture under microwave conditions. Reactions have been carried out under solvent-free conditions with considerable reduction in reaction time and improvement in yield in comparison to classical methods. The adopted procedure provides an energy and time saving protocol.

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