Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Hepatotoxic Effect of Intraperitoneal Administration of Amiodarone in Male Rabbits

Author(s): Noviara Saleem, Yasir Mehmood, Mobasher Ahmad, Merium Fatima and Sairah Hafeez Kamran

The purpose of this study was to investigate the hepatotoxic effect of intraperitoneal administration of amiodarone in male rabbits. Study was divided into 2 groups (control group and amiodarone group) and randomized control trial was used. Biochemical parameters such as ALT, AST, ALP, LDH, bilirubin, total protein, albumin, sodium, uric acid and haematological parameters were obtained before and after drug administration. Histopathological findings were also obtained. In this research we have used amiodarone in pure form and before use of amiodarone its identification and purity was determined. Significant results were obtained when compared to the control group. Based on the results it was concluded that amiodarone induced hepatotoxicity in male rabbits.


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