Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Hepatoprotective activity of Michelia champaca L. against carbontetrachloride induced hepatic injury in rats

Author(s): T. Ananthi* and R. Anuradha

Michelia champaca (Magnoliaceae), commonly known as Svarna champa is a glorious traditional Indian medicinal plant. The aim of this study was to evaluate the hepatoprotective activity against CCl4 induced liver injury in rats. Methanolic flower extract of Michelia champaca was investigated against CCl4 induced hepatotoxicity and compared with standard drug silymarin. Liver marker enzymes (AST, ALT, ALP and GGT) and Renal markers (Urea, Creatinine and Total Bilirubin) were evaluated in control and experimental rats. CCl4 treated rats elevated the liver marker enzymes and renal markers. However treatment with M.champaca significantly reversed the above changes compared to the control group as observed in the CCl4 treated rats. The results clearly indicate that flower extract of Michelia champaca possess promising hepatoprotective effect.

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