Design and synthesis of 3-(2-cinnamamidoethylsulfonyl) thiazolidine-4- carboxylate derivatives as novel angiotensin converting enzyme (ACE) inhibitors

Leifang Wu; Jie Zhang; Jianwei Xie; Bin Dai

Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us

+44 1625708989

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Design and synthesis of 3-(2-cinnamamidoethylsulfonyl) thiazolidine-4- carboxylate derivatives as novel angiotensin converting enzyme (ACE) inhibitors

Author(s): Leifang Wu, Jie Zhang, Jianwei Xie and andBin Dai

A series of 3-(2-cinnamamidoethylsulfonyl)thiazolidine-4-carboxylate derivatives were designed, synthesized, and evaluated for their angiotensin converting enzyme (ACE) inhibitory activity. Their structures were verified by 1H NMR, 13C NMR, IR, and MS. All these compounds exhibited inhibitory activity against ACE with IC50 value of 3-9 mM, and 10g showed the most potent activity.

PDF