Copper(II) acetate promoted facile synthesis of dihydropyrimidinone derivatives via a solvent free Biginelli multicomponent reaction

ImÃƒÆ’Ã‚Â¨ne Amine Khodja; Raouf Boulcina; Abdelmadjid Debache

Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Copper(II) acetate promoted facile synthesis of dihydropyrimidinone derivatives via a solvent free Biginelli multicomponent reaction

Author(s): Im�?�?�?¨ne Amine Khodja, Raouf Boulcina and Abdelmadjid Debache

A simple and efficient method of the 3,4-dihydropyrimidin-2(1H)-ones/thiones synthesis in good to high yields is described. It consists in a one-pot three-component Biginelli condensation using copper acetate as catalyst under solvent-free conditions.

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