First Issue : Journal of Chemical and Pharmaceutical Research http://jocpr.com/first-issue.html There is a great demand for herbal medicines in the developed and developing countries because of their wide biological activity, higher safety margin than synthetic drugs as a result of this Herbal drugs have a great potential in the global market. Herbal drug technology is used for converting botanicals materials into medicines, where standardization and quality control with proper integration of modern scientific techniques and traditional knowledge is important .Extensive research on DNA-based molecular markers is in progress in many research institutes all over the world.DNA -based molecular have a great utility in the herbal drug analysis and widely used for the authentification of plant species of medicinal importance. http://jocpr.com/first-issue/article-1.pdf Several five membered aromatic systems having three heteroatoms at symmetrical positions such as thiadiazoles have been studied extensively owing to their interesting pharmacological activities. This review article covers the most active thiadiazole derivatives that have shown considerable biological actions such as antimicrobial, anti-inflammatory, anticancer, anticonvulsant, antidepressant, antioxidant, radioprotective and anti-leishmanial. This review also discusses the structure activity relationship of the most potent compounds. It can act as an important tool for medicinal chemists to develop newer compounds possessing thiadiazole moiety that could be better agents in terms of efficacy and safety. http://jocpr.com/first-issue/article-2.pdf Fluorine is the 13th most abundant naturally occurring element in the Earth’s crust and is the lightest member of the halogens. It is the most electronegative and reactive of all the elements and as a result, elemental fluorine does not occur in nature but found as a fluoride mineral complexes. Exposure to fluoride beyond the recommended level for longer duration causes fluorosis. Several physical and chemical defluoridation methods have been designed to treat high fluoride concentration in ground water. There is need to develop such methods for defluoridation which would be cost effective and biodegradable. http://jocpr.com/first-issue/article-3.pdf Pharmacist plays an important role in patients healthcare. Pharmacist is now becoming more patient oriented than product oriented and have brought many changes in life of patients. There are considerable evidence that patients counseling enhances patient compliance and improve the quality of life outcomes in diabetic foot ulcers. Diabetic foot ulcer is one of the major complications of Diabetes mellitus. It occurs in 15% of all patients with diabetes and precedes 84% of all lower leg amputations. Sharp debridement and management of underlying infection and ischemia are also critical in the care of foot ulcers. Prompt and aggressive treatment of diabetic foot ulcers can often prevent exacerbation of the problem and eliminate the potential for amputation. The aim of therapy should be early intervention to allow prompt healing of the lesion and prevent recurrence once it is healed. Multidisciplinary management programs that focus on prevention, education, regular foot examinations, aggressive intervention, and optimal use of therapeutic footwear have demonstrated significant reductions in the incidence of lower-extremity amputations. Community Pharmacist play vital role Patient education regarding foot hygiene, nail care and proper footwear is crucial to reducing the risk of an injury that can lead to ulcer formation. Diabetes currently affects more than 194 million people worldwide and is expected to reach 333 million by 2025,with the maximum burdens falling upon developing countries. India considered as “Diabetic capital of the world”, alone currently counts over 35 million peopleharbouring diabetes. This is estimated to touch 73.5million by 2025 as a consequence of longer life expectancy, sedentary lifestyle and changing dietary patterns. http://jocpr.com/first-issue/article-4.pdf Many natural products from marine sources are endowed with promising anti hypertensive activity, thus representing invaluable leads in the plans for drug discovery. In this context, organic synthesis plays a decisive role in confirming (or revising) the chemical structures of the natural compounds allowing also access to suitable amounts of the target (and its analogs) for structure activity relationship (SAR) investigations. In this overview, we focus on the total and partial synthesis of marine metabolites and their related compounds discussing the retro synthetic analysis of the strategies adopted used in treatment of hypertension. http://jocpr.com/first-issue/article-5.pdf Ashoka is the most ancient tree of India, generally known as a “ashok briksh”, botanist known as a Saraca asoca (Roxb.), De.wild or Saraca indica belonging family Caesalpinaceae. Medicinal herbs are moving from fringe to mainstream use with a great number of people seeking remedies and health approaches free from side effects caused by synthetic chemicals. Saraca asoca is reported to contain glycoside, flavanoids, tannins and saponins. It is used as spasmogenic, oxytocic, uterotonic, anti-bacterial, anti-implantation, anti-tumour, anti-progestational, antiestrogenic activity against menorrhagia and anti-cancer. This review contains the Pharmacognostical account of various parts of plant, Phytochemical constituent and different reported pharmacological activity. http://jocpr.com/first-issue/article-6.pdf Migraine headaches result from a combination of blood vessel enlargement and the release ofchemicals from nerve fibers that coil around these blood vessels. During the headache, an arteryenlarges that is located on the outside of the skull just under the skin of the temple (temporal artery). This causes a release of chemicals that cause inflammation, pain, and further enlargement of the artery. A migraine headache causes the sympathetic nervous system torespond with feelings of nausea, diarrhea, and vomiting. Migraine headaches have a female predominance with a peak in prevalence in the third and fourth decades of life. Women of reproductive age are liable to develop their first migraine while pregnant or exhibit changes in the character, frequency or severity of their headaches during pregnancy and the puerperium.The purpose of this Review is to examine the pathophysiology underlying the development of migraine headaches and the association of this pathophysiology with pregnancy-related complications. We present the case of a woman with a history of migraine headaches before pregnancy, whose symptoms progressed during pregnancy in part because of increasing exposure to narcotic medications. The abortive medications for moderate or severe migraine headaches are different than OTC analgesics. Instead of relieving pain, they abort headaches by counteracting the cause of the headache, dilation of the temporal arteries. In fact, they cause narrowing of the arteries. Examples of migraine-specific abortive medications are the triptans and ergot preparations. We also discuss the diagnosis and management of migraine headaches that precede pregnancy or develop de novo during pregnancy, placing an emphasis on the distinction between primary migraine headache and headache secondary to pre-eclampsia—a relatively frequent complication of pregnancy and the puerperium. http://jocpr.com/first-issue/article-7.pdf Histoplasmosis is primarily a pulmonary disease caused by the fungus Histoplasma capsulatumwith varying symptoms.The fungus is found in high concentrations in soil contaminated withbird or bat excreta while transmission occurs via inhalation of H. capsulatum spores from the soil. The fungal infection either is cleared or the organism continues to reproduce intracellularly and disseminates throughout the body via lymphatic and hematogenous circulation. Darling, a world-leading pathologist discovered Histoplasmosis to be a fungal infection in 1905 therefore it is also called as Darling’s disease. Transmission occurs in areas like caves containing bat or bird droppings, chicken coops, birdhouses, bird roosts, or soil contaminated with such droppings. H.capsulatum can survive in soil for years and if the soil becomes airborne, it may cause Histoplasmosis. In patients that are immunosuppressed, complications are mouth ulcers, fevers,headaches, confusion, seizures, encephalopathy and infrequently, death. http://jocpr.com/first-issue/article-8.pdf Antioxidants are an inhibitor of the process of oxidation, even at relatively small concentration and thus have diverse physiological role in the body. Antioxidant constituents of the plant material act as radical scavengers, and helps in converting the radicals to less reactive species. A variety of free radical scavenging antioxidants is found in dietary sources like fruits, vegetables and tea, etc. This review presents some information about the antioxidant/antiradicals and their role in our body and also their presence in spices and herbs. http://jocpr.com/first-issue/article-9.pdf World over, the general opinion is tilting towards use of herbal drugs. The gradual rise in trade of these drugs stands testimony to this. Common reasons for this tilt are-frustrating side effects and lack of the curative value in modern medicines. Traditional systems rely heavily on herbal materials compared to modern system of medicine (allopathic). Present study judges the awareness/knowledge of common man regarding traditional systems (Ayurvedic & Homeopathic) and the overall preference of system and the preference of system in case of common ailments and medical emergency. The study also evaluates their views regarding role of pharmacist and the government in promoting the use of these drugs. The responses (500) obtained on the questionnaire sheet have been presented as Bar charts, Pie charts and Tabular form depending upon type of response along with general conclusions and suggestions. http://jocpr.com/first-issue/article-10.pdf Tuberculosis is a disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually attack the lungs. But, TB bacteria can attack any part of the body such as the kidney,spine, and brain. If not treated properly, TB disease can be fatal. TB is spread through the air from one person to another. The bacteria are put into the air when a person with active TB disease of the lungs or throat coughs or sneezes. People nearby may breathe in these bacteria and become infected. However, not everyone infected with TB bacteria becomes sick. People who are not sick have what is called latent TB infection. Even better, people with latent TB infection can take medicine so that they will not develop active TB disease. Isoniazid and rifampin are the keystones of treatment, but because of increasing resistance to them, pyrazinamide and either streptomycin sulfate or ethambutol HCL is added to regimens. If the patient is unable to take pyrazinamide, a nine-month regimen of isoniazid and rifampin is recommended. Even if susceptibility testing reveals that the patient is infected with an isoniazid-resistant strain, the isoniazid component is continued because some organisms may yet be sensitive. In addition, two drugs to which the organisms are likely to be sensitive also are incorporated into the regimen. The beginning phase of treatment is crucial for preventing the emergence of drug resistance and ensuring a good outcome. Six months is the minimum acceptable duration of treatment for all adults and children with culture-positive TB. Drug resistance may be either primary or acquired. Primary resistance occurs in patients who have had no previous antimycobacterial treatment. Tuberculosis is a highly infectious life-threatening bacterial disease with 8 million new cases and 3 million deaths reported worldwide each year to the World Health Organization. http://jocpr.com/first-issue/article-11.pdf This review examines the therapeutic potentials and mechanism of action of nitric oxide releasing non-steroidal anti inflammatory drugs. NO-releasing NSAIDS markedly improve the anti-inflammatory and antinociceptive actions efficiently and diminish gastrointestinal toxicity. The nitric oxide releasing NSAIDS may be useful to treat wide variety of diseases like colitis, cancer, thrombosis, restenosis and bronchial asthma. http://jocpr.com/first-issue/article-12.pdf Infertility in female is very often observed. It is inability to conceive and produce the child. ART (Assisted Reproductive Technology) has been carried out such as IVF, ICSI but common people cannot afford the cost of such procedures. Various allopathic, Ayurvedic and other alternatives medicines and physiotherapy with acupuncture are been effective to enhance the pregnancy and these drugs and exercises will even prevent the recurrent abortions. In this regard the present review is aimed to provide all the necessary information regarding the effective method for treatment of female infertility. http://jocpr.com/first-issue/article-13.pdf Fast dissolving Tablets are disintegrating and/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds,and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. This tablet format is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Such tablets readily dissolve or disintegrate in the saliva generally within <60 seconds. Fast- or mouth dissolving tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. Such formulations provide an opportunity for product line extension in the Many elderly persons will have difficulties in taking conventional oral dosage forms (viz., solutions,suspensions, tablets, and capsules) because of hand tremors and dysphagia. Swallowing problems also are common in young individuals because of their underdeveloped muscular and nervous systems. Other groups that may experience problems using conventional oral dosage forms include the mentally ill, the developmentally disabled, and patients who are uncooperative,on reduced liquid-intake plans, or are nauseated. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. http://jocpr.com/first-issue/article-14.pdf The paper deals with the degradation of nitrobenzene (NB) by advanced catalytic oxidation based on an anodic Fenton’s reagent. . The degradation or the conversion of nitrobenzene in to CO2, H2O and other minerals was performed by electrochemical method in the electrolysis system with direct current, with the iron anode section volume of 53ml, with potential 2.5 V, consisting of EDTA (1mM), O2 (10mg/l),Na2SO4 (0.1M), the graphite cathode section volume of 53ml consisting electrolyte of Na2SO4 (0.1M). Concentrations of NB during electrochemical degradation were monitored using high-performance liquid chromatography, (HPLC, Aligent USA). The electrochemical degradation of NB can be explained by the free radical OH* generated during electrolysis using direct current with iron anode in presence of EDTA, oxygen in weak acid pH - solution. http://jocpr.com/first-issue/article-15.pdf As a result of the numerous investigations it was found that the thermo magnetic method is most comfortable and cheap. The magnetic film is placed to the radiation area. The recording magnetic field is applied in the films plane. The influence of radiation occurs at the several parts of the magnetic film. It was found that at 973*K the perpendicular magnetic anisotropy have arise in the polycrystalline films, the films be come homogeneously magnetized. The films with the thickness of 100-150*A were obtained by the thermal evaporation of the alloys. http://jocpr.com/first-issue/article-16.pdf Thiadiazoles and their derivatives exhibit a wide variety of biological activities like antidiabetic,anti inflammatory, anti-convulsant etc.In the present study we have synthesized some substituted thiadiazoles. The structures of these synthesized compounds were confirmed by IR, NMR and CHN analysis. All the values and results of this spectral and elemental analysis are found to be in the normal range. These compounds were evaluated for various biological activities like Anti-diabetic, anti-inflammatory, anti-fungal activity. http://jocpr.com/first-issue/article-17.pdf A set of twenty N-alkyl substituted isatins derivatives with anticancer activity was subjected to the two dimensional quantitative structure activity relationships (2D-QSAR) studies using MDS 3.0 drug designing module with various combinations of thermodynamic, electronic and spatial descriptors. N-alkylation’s of isatin derivatives taken as the lead molecule and QSAR model developed using different multiple regression approach. Logarithmic inverse value of IC-50 was taken as dependent variable and Bromines Count, chi2 and SA Hydrophilic Area was taken as independent variable. The best QSAR model (r2 = 0.92, Fisher test value F=42.72, r2 se = 0.14) has acceptable statistical quality and predictive potential as indicated by the value of cross validated squared correlation coefficient (q2= 0.84). From the build model it seems to be clear that Bromines Count, chi2 and SA Hydrophilic Area contribute negative biological activity. Thus this validated model brings important structural insight to aid the design of novel anti-mycobacterial agents. http://jocpr.com/first-issue/article-18.pdf The aim of the present study is to investigate the analgesic and antipyretic activity of whole parts of the plant Sphaeranthus indicus Linn. (Compositae) on albino rats by Eddy’s hot plate, Tail immersion and Brewer’s yeast induced pyrexia method respectively. Dried powder plant materials were subjected to sucessesive solvent extraction taking Petroleum ether,Benzene, Chloroform, Ethanol and triple distilled water. The different extracts at a dose of 200mg/kg and 400mg/kg body weight were subjected to analgesic and antipyretic activity. The petroleum ether, chloroform and ethanol extracts showed significant analgesic activity in both doses (p<0.001 & p<0.01) from 1 hour onwards as compared to the standard drug diclofenac sodium. The chloroform and ethanol extracts showed potential significant antipyretic activity (p<0.05) from 1 hour onwards where as aqueous extracts exhibit activity from 2 hours onward as compared to the standard drug paracetamol amongst various extracts. http://jocpr.com/first-issue/article-19.pdf Synthesis of 2-amino-5-hydroxy-4-phenyl-7-methylchromeno-3-carbonitrile. 1 obtained by the reaction of 5-methyl resorcinol and benzylidine malonitrile used in synthetic routes to several heterocyclic compounds containing pyrimidine, pyridine, chromene, oxazine, thiazine and pyrrol by reaction of 1 with various reagents such as formamide, formic acid, phenylisothiocyanate, urea, thiourea, semicarbazide thiosemicarbazide to give chromenopyrimidine derivatives 2, 3, 4, 9, 10a,b, 11a,b respectively. The reaction of 1 with acetic anhydride under different conditions to give 5, 6, 7 followed by reactions with hydrazine hydrates, formamide, hydroxylamine hydrochloride to give chromenopyrimidine derivatives 8a-c. The interaction between 1 with cyclohexane, malonitrile, carbon disulfide gave 12, 13, 14 which was cyclised to give thiazine15 and the O-alkylation of 1 by using ethylbromoacetate or chloroacetonitrile to give 16a,b and chromenopyrrol derivatives 17. http://jocpr.com/first-issue/article-20.pdf The behavior of chlordiazepoxide has been studied using dc-polarography at dropping mercury electrode (DME) and cyclic voltammetry at glassy carbon electrode (GCE). In Britton-Robinson buffers, the drug developed three reduction irreversible waves in acidic solutions, and only two waves in alkaline media. The adsorptive stripping voltammetric behavior of chlorodiazepoxide was studied at GCE, and a sensitive voltammetric method was evaluated applying linear-sweep mode for quantitative determination of the drug in pure form and commercial tablets. A linear relationship between peak current and drug concentration was obtained in the concentration range 2x10-7 to 5x10-6 mol l-1 of the drug at pH = 4.0, with a detection limit of 5x10-8 M. The drug was determined in capsules with a percentage recovery of 100.65 ± 1.83 (n=5). http://jocpr.com/first-issue/article-21.pdf The aim of the present study was to evaluate and compare the antimicrobial activity of Bougainvillea glabra ‘Snow White’ leaves extract with Bougainvillea glabra ‘Choicy’ leaves extract. Bougainvillea glabra ‘Snow White’ is a cultivated variety of Bougainvillea glabra ‘Choicy’ which have white bracts with greenish veins. Antimicrobial activity of different solvent extracts of these plant leaves were tested against Gram positive and Gram negative bacterial strains by observing the zone of inhibition. Antimicrobial activity was done by disc diffusion method at a concentration of 500 µg/disc of the extract, using ofloxacin (5µg/disc) as the standard. The bacterial strains used in the study were Staphycococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhii, Klebsiella pneumoniae, Proteus vulgaris, and Vibrio cholerae. Hydroalcoholic extract was more active against all bacteria. Bougainvillea glabra ‘snow white’ was not effective against Bacillus subtilis and Micrococcus leuteus while B. glabra ‘choicy’ was not effective against Proteus vulgaris. http://jocpr.com/first-issue/article-22.pdf Two complexes of [Co(en)2phen]3+ (1) and [Co(en)2bpy]3+ (2) have been synthesized and characterized by UV/VIS, IR, 1H NMR spectral methods. Absorption spectroscopy, emission, viscosity measurements, DNA melting and DNA photo cleavage have investigated the binding of the two complexes with calf thymus DNA. The spectroscopic studies together with viscosity measurements and DNA melting studies support that both of these complexes bind to CT DNA by groove mode, (1) binds more avidly to CT DNA than (2) which is consistent with the extended planar and p system of 1, 10, phenanthroline. Noticeably, the two complexes have been found to be efficient photosensitisers for strand scissions in plasmid DNA. http://jocpr.com/first-issue/article-23.pdf 2-[(3'-chloro-4'-nitro phenylamino) methyl]phenol 1 underwent facile condensation with various phosphorus dichlorides 2a-j in the presence of TEA in dry THF at 60-65 and afforded corresponding 1,3,2 ?5 -benzoxaphosphinin-2-one derivatives 3a-j. Their chemical structures were characterized using IR, 1H, 13C, 31P NMR and mass spectral studies. All the above compounds were screened for anti-microbial activity and their bioassay showed them to possess significant antimicrobial activity. http://jocpr.com/first-issue/article-24.pdf A Simple and rapid dissolution test method for Phenylephrine Hydrochloride Pellets - 20%W/W has been developed and validated. Based on the stability and nature of the drug, dissolution experiments were conducted in different mediums in various time intervals with Basket at 100 rpm(resolution per minute). Dissolution was found to be NMT 25% over a period of one hour, 30-50% in 2nd hour, 50-70% in 4th hour, at 8th hour NTL 75%. The quantitative recoveries of the drug from semi formulations were established indicating non interference of excipients. The dissolution profile for pellets were considered satisfactory and this could be utilized for the Quality control Analysis of Phenylephrine Hydrochloride Pellets 20%W/W. http://jocpr.com/first-issue/article-25.pdf Herbal formulations always have attracted considerable attention because of their good activity and comparatively lesser or nil side effects with synthetic drugs. The objective of present study involves preparation of herbal hair oil using amla, hibiscus, brahmi, methi and its evaluation for increase in hair growth activity. Each drug was tested for their hair growth activity in a concentration range for 1-10% separately. Based on these results mixture of crude drugs fruits of Embelica officinalis, flowers of Hibiscus rosa sinensis, leaves of Bacopa monnieri and seeds of Trigonella foenumgraecum were prepared in varying concentration in the form of herbal hair oil by three different oils preparation techniques (direct boiling, paste and cloth method) and were tested for hair growth activity. The oil of different concentrations were characterized for proximate analysis including moisture content, total ash, acid insoluble ash, water soluble ash, water insoluble ash, sulphated ash. The formulations were also subjected to chromatographic determination and chemical tests to determine the presence of active constituents in the drugs. But looking towards the formulation viscosity the maximum concentration of combined drug was found to be 30% at their maximum level. The formulation containing 7.5% of each drug used for the study and showed excellent hair growth activity with standard (2% minoxidil ethanolic solution) by an enlargement of follicular size and prolongation of the anagen phase. It holds the promise of potent herbal alternative for minoxidil. Excellent results of hair growth were seen in formulation prepared by boiling method of oils preparation technique. http://jocpr.com/first-issue/article-26.pdf The antimicrobial activity of the various extracts of the leaves of Anthocephalus cadamba has been studied by agar cup plate diffusion method. Significant antibacterial and antifungal activity was shown by petroleum ether, chloroform and acetone extracts. http://jocpr.com/first-issue/article-27.pdf The present work described a simple, precise, accurate and linear reverse phase HPLC method for determination of Phenoxymethy penicillin potassium from tablet formulations. The determination was carried out on a Hypersil, ODS, C-18 (30cm 4mm) (3 to 10mm) 5µ column using a mobile phase of water: acetonitrile: glacial acetic acid (500:500:5.75).The flow rate and run time were 1ml/min and 10 min respectively. The method was reproducible with theoretical plates and % RSD. http://jocpr.com/first-issue/article-28.pdf The kinetic study of 3-chloroacetylacetone and thioureas has been carried out in ethanol. Thioureas used for study are thiourea, phenyl thiourea, p-methyl phenyl thiourea, p-ethoxy phenyl thiourea and p-chlorophenyl thiourea. The second order rate constants for these reaction were reported. The rate of reaction is first order with respect to 3-chloroacetylacetone and first order with respect to thioureas. The effect of substituents on the rate of reaction was also studied. Thermodynamic parameters are used to explain the nature of the reaction. The reaction products are isolated and characterized. Possible reaction mechanism for the reaction will be proposed and details of the kinetics will be discussed. http://jocpr.com/first-issue/article-29.pdf An extensive knowledge of the soil temporal variability of micronutrients and how this variation affects the environments is imperative to a wide range of discipline within agricultural science for optimum crop production and eco system preservation. Attempt has been maid to examine the the soil temporal variability of micronutrients viz. cadmium, cobalt, chromium, copper, mercury, nickel, lead, zinc and SAR in pre-monsoon and post- monsoon seasons from March 2008 to September 2008 around kurkumbh industrial area. The concentration of some micronutrients is generally high in post monsoon season. The fertilizer input rate and continuous discharging of industrial waste water on soil surface are causing nutrient imbalance. http://jocpr.com/first-issue/article-30.pdf A new RP-HPLC method was developed for the determination of Lamivudine in the bulk drug and tablet dosage forms and it was applied for the in-vitro drug dissolution studies. Isocratic elution mode with a mixture of methanol and water in the ratio of (89:11) was selected as the mobile phase with a C18 column (250 x 4.6mm, 5µ ) for separation. This mixture was found to be appropriate allowing good elution for the Lamivudine at retention time 2.72 minute at flow rate of 1 ml/min and detection wavelength at 272nm. The linearity was found in the concentration range of Lamivudine 5-100 µg/ml. The liquid chromatography method was extensively validated for linearity, range, accuracy, precision (intermediate precision, repeatability) and specificity. All these analytical validation parameters were observed and the %RSD was determined which indicates the useful of RP-HPLC method for determination of Lamivudine in the bulk drug & tablets dosage form. http://jocpr.com/first-issue/article-31.pdf The oxidation of secondary alcohol was investigated to compare the polymer substrate supported reagent with a commercially available cross-linked polymeric reagent. The reagent supported on anion exchange resin was found to be more efficient in the oxidation reaction. The reagent is very easily separated from the reaction mixture and can be manually removed from the reaction mixture, which remains clear during and after the reaction. The kinetics of oxidation of secondary alcohol with chromic acid supported on anion exchange resins like Duolite A-101[Cl-] and Ambersep 900[ OH ] in 1,4-dioxane has been studied. The reaction is found to be of zero order each in concentration of alcohol and oxidant. The stoichiometric coefficient of the reaction has been found to be 2:1. The oxidation products have been isolated and characterized by their derivatives, UV and FT-IR spectral studies. The effect of substituent’s on the rate of oxidation and activation parameters for the overall reactions has been computed from Arrhenius plot. http://jocpr.com/first-issue/article-32.pdf Anti-inflammatory and wound healing activity of topical application of Curcuma aromatica Salisb. rhizome extract and is cream formulations in Arachidonic acid -induced ear inflammation and excision wound model was confirmed in albino mice. The extraction of these rhizomes was carried out by ethanol. The ethanol extract and formulations exhibited significant anti- inflammatory activity in arachidonic acid - induced ear inflammation. It also showed significant wound healing activity in excision wound model. Thus, resultant anti-inflammatory activity might be due to effects on several mediators and arachidonic acid metabolism involving cyclo- oxygenase pathway resulting in prostaglandin synthesis. http://jocpr.com/first-issue/article-33.pdf A simple, fast and accurate method has been developed for the determination of Ethanol and Acetone in Clarithromycin granules by Gas Chromatography. The analysis was carried out on Shimadzu GC-2010 Gas Chromatograph. The column used was 30m x 0.32 mm Id fused silica analytical column ZB-624, 1.80 mm. (6% cyanopropylphenyl 94 % dimethylpolysiloxane as a stationary phase).The detector used was FID detector. The validation of proposed method was also carried out. http://jocpr.com/first-issue/article-34.pdf Determination of thiosulphate using photochemical exchange reaction of sodium nitroprusside has been investigated. It is an inexpensive, faster and convenient quantitativemethod. Sodium nitroprusside is a photolabile complex which undergoes photochemical ligand exchange reactions rapidly. Some recent efforts have been made to utilise such reactions for the estimation of some nitrogen containing anions and electron rich organic molecules. The progress of the reaction is observed spectrophotometrically. The effects of different parameters like pH, change of concentration of sodium nitroprusside, concentration of ligands, light intensity etc. on percentage error was investigated. The efforts were made to minimise the percentage error and some optimum conditions were obtained. Such reaction can be used for the determination of thiosulphate in the range of millimoles to micromoles;hence it is important to know whether such estimations can be done successfully and that too with the desired accuracy. http://jocpr.com/first-issue/article-35.pdf A simple, selective, rapid, precise and economical reverse phase high-pressure liquid chromatographic method has been developed for the simultaneous estimation of Paracetamol and Etoricoxib from pharmaceutical formulation. The method was carried out on an inertsil ODS, 5µ , C8-3 column, with a mobile phase consisting of methanol: acetonitrile: phosphate buffer pH 3.5 (40:20:40 v/v) at a flow rate of 1.0 ml/min. Detection was carried out at 242. The retention time of Paracetamol and Etoricoxib were 3.27, 6.12 min. respectively. The developed method was validated in terms of accuracy, precision, linearity, Limit of detection, Limit of quantitation.The proposed method can be used for estimation of these drugs in combined dosage form for routine analysis. http://jocpr.com/first-issue/article-36.pdf Dispersible tablets of Norfloxacin were prepared using natural substances as disintegrant such as Ispaghula husk powder, Cassia tora powder, Cassia tora powder (defatted), and Cassia nodosa powder in different concentration by direct compression method. Formulations were evaluated for the standard of dispersible tablets and were compared with marketed products. It was observed that all the formulations were acceptable with reasonable limits of standard required for dispersible tablets. The study reveals that natural gums used as disintegrants were effective in low concentration. http://jocpr.com/first-issue/article-37.pdf