Synthesis, antimicrobial properties of 3-(3’-Chloro-4’-nitrophenyl)-2-(substituted phenoxy)-3,4-dihydro-2H-1,3,2 ?5–benzoxaphosphinin-2-ones

 

By A. Bala krishna, S. Annar, M. Veera Narayana Reddy, G. Chandra Shekar Reddy, C. Suresh Reddy and S. K. Nayak

 

Abstract

2-[(3'-chloro-4'-nitro phenylamino) methyl]phenol 1 underwent facile condensation with various phosphorus dichlorides 2a-j in the presence of TEA in dry THF at 60-65 and afforded corresponding 1,3,2 ?5 -benzoxaphosphinin-2-one derivatives 3a-j. Their chemical structures were characterized using IR, 1H, 13C, 31P NMR and mass spectral studies. All the above compounds were screened for anti-microbial activity and their bioassay showed them to possess significant antimicrobial activity.

Key words: Benzoxaphosphin-2-ones, spectral analysis, anti-microbial activity.

 

download complete article in pdf format